Blastocyst Stage Embryo Transfer


Advantages of blastocyst transfer

  • 1:- Theoretically, an embryo that dies in the laboratory before it develops into a blastocyst would also not have continued to develop in the uterus.
  • 2 :- The pregnancy rate per transfer is higher when blastocyst embryos are transferred on day 5 to 7 than when earlier-stage embryos are transferred on day 2 or 3.

Blastocyst Embryo Transfer Background Information

Fertilization of an egg by a sperm occurs soon after its release from the ovary (ovulation) into the fallopian tube to form a single cell embryo (zygote) containing the genetic material of the sperm and egg.

The zygote then divides progressively into a multi-cell embryo. When the embryo contains about 12-16 cells, it is called a “morula”. After 5-6 days, the embryo contains many cells and forms a cystic cavity termed the blastocoel within its center.

At this stage, the embryo is called a “blastocyst” and has undergone the 1st step in differentiation.

Until recently, culture of embryos, in the laboratory, to the blastocyst stage was very difficult because the several culture media that were used to supply nutrients to the embryos were inadequate for extended embryo growth in the laboratory.

Therefore, many embryos died before they developed into blastocysts. Improved culture media and advanced techniques are now available that sustain embryo growth in the laboratory for several days prior to implantation.

Many IVF centers now culture embryos to the later blastocyst stage before transferring them into a woman’s uterus in an attempt to maintain or increase the pregnancy rate. Fewer of the later-stage embryos are transferred to reduce the risk of multiple gestations.

After Embryo Transfer

TDuring your IVF treatment cycle, once your embryos have been transferred back to the uterus, there is a 2 week waiting period before you can find out if you are pregnant or not.

This wait can create havoc in your life. There is a huge amount of advice and tips about what to do or not do during this period. You are anxious not to do anything which could harm your precious embryos in any way.

Your stress levels are sky-high because you want to ensure that everything is perfect, so your embryos can implant successfully.  Your major fear is that you will do something bad which will cause them to get dislodged or rejected!

Someone might suggest a particular diet during this period , while others might have a completely opposite opinion. It is said that having foods like papaya can increase the body’s internal temperature, which in turn may harm the embryo.

You are likely to be overwhelmed by the quantity of conflicting advice that you get every day. This can exacerbate your stress levels or make you even more over cautious or excessively emotional.

This waiting period can harm your emotional balance. It is normal to be protective towards your embryos but it is inappropriate to be obsessed every moment about the IVF treatment outcome.

The fact is that nothing you eat, drink or do will harm the embryo. You can lead a normal daily life even after the embryo transfer . No activity can be harmful to the embryo which is safe and snug and secure in your uterus .

Leading a normal life may actually help you tackle the stress better.  Your mind would be occupied in regular work rather than obsessing about the result – over which you have no control in any case.

It is important to understand that IVF is not an artificial pregnancy technique. It just provides assistance for patients who are unable to conceive in the natural way.

Fertile women who conceive naturally may not even know that they are pregnant until they miss their period, so they never worry – so why should you? In the same manner, after the embryo transfer, the biological processes of your body continue working perfectly. They will work efficiently on their own and are not by external habits or actions.

Embryo Transfer Faqs

What is infertility ? 

Infertility is defined as the failure to conceive after a year of regular unprotected intercourse, or the inability to carry a pregnancy to a live birth. 

What is primary & secondary infertility ? 

Primary infertility- when the woman has never conceived

Secondary infertility- when the woman has conceived atleast once but can not get pregnant again

What causes infertility ? 

Most infertility results from physical problems in either the male partner’s or the female partner’s reproductive system, or both. Some causes include problems with <br>

The man's reproductive system<br>

The woman's fallopian tubes<br>

The woman's uterus and / or cervix<br>

The woman's ovulation.<br>

Unknown reasons<br>


How many couples are affected by infertility ? 

One in six couples is affected by some degree of infertility and need some kind of medical intervention for conception. 


How does natural conception occur ? 

Naturally conception occurs when the male’s sperm meets the woman's egg. This typically takes place in one of the woman’s fallopian tubes and the fertilized egg then travels to the uterus and is implanted in the uterine lining.<br> For pregnancy to take place, fertilization of the egg must be followed by a successful implantation. Only one egg is released for fertilization in each menstrual cycle.<br> If this egg is not fertilized, conception will not be possible again until the next cycle. 


How is infertility diagnosed ? 

A complete medical history and a physical exam are the first step in diagnosing fertility problems. Both partners need to be evaluated. <br>The couple may also need blood tests, semen analysis and ultrasound exams or exploratory surgery for the woman. 


How is infertility in a woman treated ? 

Once the cause for infertility is determined, treatment can be planned. Sometimes, simple counseling or simple medication will solve the problem. In some cases, surgery is required. 

How is infertility in a man treated ? 

Problems in the male reproductive organs can often be resolved with medication and, if required, with surgery. 

What increases a man’s risks of infertility ? 

Sperm quality and quantity can be affected by overall health and lifestyle. Some things that may reduce sperm number and / or quality include alcohol, drugs, stress, environmental toxins, smoking, health problems, certain medicines, radio or chemotherapy and age. 


What increases a woman's risk of infertility ? 

Things that affect woman's fertility include age, stress, poor diet, obesity, underweight, smoking, STDs, hormonal problems and other health problems. 


How does age affect woman's fertility ? 



For woman<br>

The quality of eggs in the ovaries decline with age.<br>

The ability of an egg to become fertilized may also decrease over time, lowering the odds of conception<br>

A woman produces fewer eggs with time.<br>

Over time, changes in hormones can cause difficulties with ovulation. Miscarriage rates increase with age.


 Is infertility hereditary ? 

Most infertility problems are not hereditary. 


How successful are infertility treatments ? 

Improvements in medication, surgery and ART make pregnancy possible for a majority of the couples pursuing treatments. Success rates have drastically improved for couples taking treatment under ART.<br> There are various factors which influence success in ART. On an average, the success rates with IUI are around 15-20% & 40-50% with IVF.